Sequence Detail

ID/Version

P26645 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Myristoylated alanine-rich C-kinase substrate; Short=MARCKS;

Provider

SWISS-PROT

Sequence

Polypeptide 309 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Marcks	myristoylated alanine rich protein kinase C substrate	67	125	4	13

Sequence references in MGI

J:3038 Herget T, et al., Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. Eur J Biochem. 1992 Oct 1;209(1):7-14
J:11069 Seykora JT, et al., Cloning and molecular characterization of the murine macrophage 68-kDa protein kinase C substrate and its regulation by bacterial lipopolysaccharide. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2505-9
J:32127 Wu M, et al., Neural tube defects and abnormal brain development in F52-deficient mice. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2110-5
J:168209 Yamauchi E, et al., Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin. Nat Struct Biol. 2003 Mar;10(3):226-31
J:270211 Yang P, et al., Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:323745 Brudvig JJ, et al., MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network. Sci Rep. 2018 Sep 5;8(1):13278