Sequence Detail

ID/Version

P26618 Q62046 Q8C4N3 Q3TQ37 Q7TSJ3 (UniProt | EBI)

Last sequence update: 2008-02-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Platelet-derived growth factor receptor alpha; Short=PDGF-R-alpha; Short=PDGFR-alpha; EC=2.7.10.1;AltName: Full=Alpha platelet-derived growth factor receptor;AltName: Full=Alpha-type platelet-derived growth factor rec

Provider

SWISS-PROT

Sequence

Polypeptide 1089 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdgfra	platelet derived growth factor receptor, alpha polypeptide	162	277	3	49

Sequence references in MGI

J:1680 Do MS, et al., Mouse platelet-derived growth factor alpha receptor: sequence, tissue-specific expression and correlation with metastatic phenotype. Oncogene. 1992 Aug;7(8):1567-75
J:30456 Wang C, et al., Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. Mol Cell Biol. 1990 Dec;10(12):6781-4
J:41814 Soriano P, The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development. 1997 JUL;124(14):2691-2700
J:63212 Karlsson L, et al., Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development. 2000 Aug;127(16):3457-66
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:177243 Schneider L, et al., Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem. 2010;25(2-3):279-92
J:281256 Schmid FM, et al., IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases. J Cell Biol. 2018 Jan 2;217(1):151-161
J:284103 Hong YK, et al., Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors. J Invest Dermatol. 2019 Oct;139(10):2204-2214.e7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89