Sequence Detail

ID/Version

P26361 Q9JKQ6 Q63894 Q63893 (UniProt | EBI)

Last sequence update: 2002-01-31
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Cystic fibrosis transmembrane conductance regulator; Short=CFTR;AltName: Full=ATP-binding cassette sub-family C member 7;AltName: Full=Channel conductance-controlling ATPase; EC=5.6.1.6 {ECO:0000250|UniProtKB:P13569};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 1476 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cftr	cystic fibrosis transmembrane conductance regulator	111	109	3	28

Sequence references in MGI

J:11319 Tata F, et al., Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene. Genomics. 1991 Jun;10(2):301-7
J:11413 Yorifuji T, et al., Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator. Genomics. 1991 Jul;10(3):547-50
J:19216 Denamur E, et al., Analysis of the mouse and rat CFTR promoter regions. Hum Mol Genet. 1994 Jul;3(7):1089-94
J:23850 Ratcliff R, et al., Production of a severe cystic fibrosis mutation in mice by gene targeting. Nat Genet. 1993 May;4(1):35-41
J:48374 Delaney SJ, et al., Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nat Genet. 1993 Aug;4(4):426-31
J:60184 Ellsworth RE, et al., Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1172-7
J:144738 Yang D, et al., IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest. 2009 Jan;119(1):193-202
J:158652 Lu M, et al., Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6082-7
J:176213 Gee HY, et al., Rescue of DeltaF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway. Cell. 2011 Sep 2;146(5):746-60
J:185780 Chavez JC, et al., Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan;86(1):1-14
J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41
J:240085 Shah VS, et al., Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science. 2016 Jan 29;351(6272):503-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89