Sequence Detail

ID/Version

P24161 P29020 Q9D3G3 (UniProt | EBI)

Last sequence update: 1992-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=T-cell surface glycoprotein CD3 zeta chain;AltName: Full=T-cell receptor T3 zeta chain;AltName: CD_antigen=CD247;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 164 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd247	CD247 antigen	52	98	4	16

Sequence references in MGI

J:9058 Weissman AM, et al., Molecular cloning of the zeta chain of the T cell antigen receptor. Science. 1988 Feb 26;239(4843):1018-21
J:9902 Baniyash M, et al., The isolation and characterization of the murine T cell antigen receptor zeta chain gene. J Biol Chem. 1989 Aug 5;264(22):13252-7
J:15579 Liu CP, et al., Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine. EMBO J. 1993 Dec;12(12):4863-75
J:21458 Clayton LK, et al., CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5202-6
J:25927 Jin YJ, et al., Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells. Proc Natl Acad Sci U S A. 1990 May;87(9):3319-23
J:76854 Pandey A, et al., A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem. 2002 May 24;277(21):19131-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:167764 Xu HP, et al., The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron. 2010 Feb 25;65(4):503-15
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89