Sequence Detail

ID/Version

P23804 Q61040 Q64330 Q91XK7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase Mdm2; EC=2.3.2.27 {ECO:0000269|PubMed:14642282};AltName: Full=Double minute 2 protein;AltName: Full=Oncoprotein Mdm2;AltName: Full=RING-type E3 ubiquitin transferase Mdm2 {ECO:0000305};AltName: Full=p53-bi

Provider

SWISS-PROT

Sequence

Polypeptide 489 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mdm2	transformed mouse 3T3 cell double minute 2	158	138	3	81

Sequence references in MGI

J:18287 Fakharzadeh SS, et al., Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 1991 Jun;10(6):1565-9
J:32892 de Oca Luna RM, et al., The organization and expression of the mdm2 gene. Genomics. 1996 May 1;33(3):352-7
J:36310 Jones SN, et al., Genomic organization of the mouse double minute 2 gene. Gene. 1996 Oct 10;175(1-2):209-13
J:53589 Saucedo LJ, et al., Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light. J Biol Chem. 1999 Mar 19;274(12):8161-8
J:83418 Boyd MT, et al., A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem. 2000 Oct 13;275(41):31883-90
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127208 Tompkins VS, et al., A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J Biol Chem. 2007 Jan 12;282(2):1322-33
J:169789 Bernardi R, et al., PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol. 2004 Jul;6(7):665-72
J:222100 Zhu D, et al., BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015 Apr;125(4):1497-508
J:241062 Sasaki M, et al., Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011 Jul 31;17(8):944-51
J:275141 Elkholi R, et al., MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. Mol Cell. 2019 May 2;74(3):452-465.e7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89