Sequence Detail

ID/Version

P23798 (UniProt | EBI)

Last sequence update: 1992-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polycomb group RING finger protein 2;AltName: Full=DNA-binding protein Mel-18;AltName: Full=Melanoma nuclear protein 18;AltName: Full=RING finger protein 110;AltName: Full=Zinc finger protein 144; Short=Zfp-144;

Provider

SWISS-PROT

Sequence

Polypeptide 342 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcgf2	polycomb group ring finger 2	49	107	2	42

Sequence references in MGI

J:10834 Tagawa M, et al., Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J Biol Chem. 1990 Nov 15;265(32):20021-6
J:30374 Kanno M, et al., mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J. 1995 Nov 15;14(22):5672-8
J:33159 Akasaka T, et al., A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development. 1996 MAY;122(5):1513-1522
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:91148 Kajiume T, et al., Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells. Exp Hematol. 2004 Jun;32(6):571-8
J:97744 Miyazaki M, et al., Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway. J Immunol. 2005 Mar 1;174(5):2507-16
J:100027 Isono K, et al., Mammalian polyhomeotic homologues phc2 and phc1 act in synergy to mediate polycomb repression of hox genes. Mol Cell Biol. 2005 Aug;25(15):6694-706
J:113574 Miyazaki K, et al., Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18. Immunol Lett. 2002 Feb 1;80(2):139-43