Sequence Detail

ID/Version

P23506 Q810R4 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein-L-isoaspartate(D-aspartate) O-methyltransferase {ECO:0000305|PubMed:12023972}; Short=PIMT; EC=2.1.1.77 {ECO:0000269|PubMed:12023972, ECO:0000269|PubMed:16923807};AltName: Full=L-isoaspartyl protein carboxyl methyltran

Provider

SWISS-PROT

Sequence

Polypeptide 227 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcmt1	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	28	96	3	50

Sequence references in MGI

J:2260 Romanik EA, et al., Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase. Gene. 1992 Sep 10;118(2):217-22
J:19461 Galus A, et al., Structural analysis of transcripts for the protein L-isoaspartyl methyltransferase reveals multiple transcription initiation sites and a distinct pattern of expression in mouse testis: identification of a 5'-flanking sequence with promoter activity. Arch Biochem Biophys. 1994 Aug 1;312(2):524-33
J:78144 Farrar C, et al., Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. J Biol Chem. 2002 Aug 2;277(31):27856-63
J:117214 Vigneswara V, et al., Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme. J Biol Chem. 2006 Oct 27;281(43):32619-29
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89