Sequence Detail

ID/Version

P23475 O88212 Q8QZX7 Q62382 Q3UJL8 Q6GTV8 Q62453 Q62027 (UniProt | EBI)

Last sequence update: 2008-02-05
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=X-ray repair cross-complementing protein 6; EC=3.6.4.-; EC=4.2.99.-;AltName: Full=5'-deoxyribose-5-phosphate lyase Ku70; Short=5'-dRP/AP lyase Ku70;AltName: Full=ATP-dependent DNA helicase 2 subunit 1;AltName: Full=AT

Provider

SWISS-PROT

Sequence

Polypeptide 608 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Xrcc6	X-ray repair cross complementing 6	96	100	3	53

Sequence references in MGI

J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
J:32970 Oderwald H, et al., Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes. FEBS Lett. 1996 Mar 18;382(3):313-8
J:33936 Takiguchi Y, et al., Genomic structure and chromosomal assignment of the mouse Ku70 gene. Genomics. 1996 Jul 1;35(1):129-35
J:47726 Fukumura R, et al., Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint. J Biol Chem. 1998 May 22;273(21):13058-64
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:82574 Leskov KS, et al., Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem. 2003 Mar 28;278(13):11590-600
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8
J:287062 Shao Z, et al., DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature. 2020 Mar;579(7798):291-296
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:311900 Liu X, et al., ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Res. 2020 Sep;30(9):732-744
J:326401 Wang Y, et al., SETD4-mediated KU70 methylation suppresses apoptosis. Cell Rep. 2022 May 10;39(6):110794