Sequence Detail

ID/Version

P23440 Q80UF0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta {ECO:0000305}; Short=GMP-PDE beta; EC=3.1.4.35 {ECO:0000250|UniProtKB:P35913};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 856 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	12	103	3	23

Sequence references in MGI

J:10777 Bowes C, et al., Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments]. Nature. 1990 Oct 18;347(6294):677-80
J:10983 Baehr W, et al., Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase alpha- and beta-subunits, and identification of beta'-, a putative beta-subunit isozyme produced by alternative splicing of the beta-subunit gene. FEBS Lett. 1991 Jan 14;278(1):107-14
J:11513 Pittler SJ, et al., Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8322-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:219703 Nishiguchi KM, et al., Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. Nat Commun. 2015;6:6006
J:281284 Ota W, et al., Impaired Circadian Photoentrainment in Opn5-Null Mice. iScience. 2018 Aug 31;6:299-305