Sequence Detail

ID/Version

P23204 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Peroxisome proliferator-activated receptor alpha; Short=PPAR-alpha;AltName: Full=Nuclear receptor subfamily 1 group C member 1;

Provider

SWISS-PROT

Sequence

Polypeptide 468 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppara	peroxisome proliferator activated receptor alpha	187	146	4	22

Sequence references in MGI

J:10775 Issemann I, et al., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators [see comments]. Nature. 1990 Oct 18;347(6294):645-50
J:17040 Gearing KL, et al., Structure of the mouse peroxisome proliferator activated receptor alpha gene. Biochem Biophys Res Commun. 1994 Feb 28;199(1):255-63
J:29812 Jones PS, et al., Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes. Eur J Biochem. 1995 Oct 1;233(1):219-26
J:43438 Zhu Y, et al., Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem. 1997 Oct 10;272(41):25500-6
J:62059 Zhu Y, et al., Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J Biol Chem. 2000 May 5;275(18):13510-6
J:85352 Fu J, et al., Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 2003 Sep 4;425(6953):90-3
J:129744 Finck BN, et al., Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 2006 Sep;4(3):199-210
J:138823 Seale P, et al., PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:157324 Chakravarthy MV, et al., Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 2009 Aug 7;138(3):476-88
J:255965 Jordan SD, et al., CRY1/2 Selectively Repress PPARdelta and Limit Exercise Capacity. Cell Metab. 2017 Jul 5;26(1):243-255.e6
J:264679 Zhao Z, et al., Hepatic PPARalpha function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology. 2018 Jul;68(1):289-303