Sequence Detail

ID/Version

P22725 Q8VCV6 Q8BM17 Q8BMF9 (UniProt | EBI)

Last sequence update: 2008-11-04
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein Wnt-5a;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 380 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wnt5a	wingless-type MMTV integration site family, member 5A	326	242	3	16

Sequence references in MGI

J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
J:52600 Yamaguchi TP, et al., A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development. 1999 Mar;126(6):1211-23
J:63226 Tanaka K, et al., The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem. 2000 Jul;267(13):4300-11
J:85368 Topol L, et al., Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol. 2003 Sep 1;162(5):899-908
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107727 Mikels AJ, et al., Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 2006 Apr;4(4):e115
J:154679 Fu J, et al., Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18598-603
J:187646 Zhang X, et al., Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22;149(7):1565-77
J:236814 Kim S, et al., The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 Jul;18(7):752-64