Sequence Detail

ID/Version

P22682 Q8CEA1 Q3U527 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase CBL; EC=2.3.2.27 {ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:20100865};AltName: Full=Casitas B-lineage lymphoma proto-oncogene;AltName: Full=Proto-oncogene c-Cbl;AltName: Full=RING-type E3 ubiquitin t

Provider

SWISS-PROT

Sequence

Polypeptide 913 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cbl	Casitas B-lineage lymphoma	127	101	3	28

Sequence references in MGI

J:35411 Latour S, et al., Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem. 1996 Sep 13;271(37):22782-90
J:35635 Fournel M, et al., Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. J Exp Med. 1996 Jan 1;183(1):301-6
J:37010 Blake TJ, et al., The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene. 1991 Apr;6(4):653-7
J:46223 Ribon V, et al., A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol. 1998 Feb;18(2):872-9
J:48737 Miyake S, et al., The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7927-32
J:56338 Lee PS, et al., The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J. 1999 Jul 1;18(13):3616-28
J:76785 Loreto MP, et al., Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. Mol Cell Biol. 2002 Jun;22(12):4241-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161729 Kim J, et al., The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors. Mol Cell Biol. 2010 Apr;30(7):1582-92
J:177152 Fasen K, et al., Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. Traffic. 2008 Feb;9(2):251-66
J:193456 Chen W, et al., Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell. 2013 Jan 31;152(3):467-78
J:227464 Feng L, et al., SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Cell Biochem Funct. 2011 Oct;29(7):589-96
J:281256 Schmid FM, et al., IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases. J Cell Biol. 2018 Jan 2;217(1):151-161
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89