Sequence Detail

ID/Version

P22646 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=T-cell surface glycoprotein CD3 epsilon chain;AltName: Full=T-cell surface antigen T3/Leu-4 epsilon chain;AltName: CD_antigen=CD3e;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 189 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd3e	CD3 antigen, epsilon polypeptide	80	113	2	29

Sequence references in MGI

J:8902 Gold DP, et al., Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7649-53
J:9461 Clevers H, et al., Characterization and expression of the murine CD3-epsilon gene. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8623-7
J:70267 Sun ZJ, et al., Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer. Cell. 2001 Jun 29;105(7):913-23
J:72144 DeJarnette JB, et al., Specific requirement for CD3epsilon in T cell development. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14909-14
J:156722 Wang Y, et al., A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 2009 Dec;7(12):e1000253
J:209827 Borroto A, et al., Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo. J Immunol. 2014 Mar 1;192(5):2042-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:312760 Bettini ML, et al., Membrane association of the CD3epsilon signaling domain is required for optimal T cell development and function. J Immunol. 2014 Jul 1;193(1):258-67