Sequence Detail

ID/Version

P22387 P70203 P97338 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Endothelin-1; Short=ET-1;AltName: Full=Preproendothelin-1; Short=PPET1;Contains: RecName: Full=Big endothelin-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 202 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Edn1	endothelin 1	220	132	3	12

Sequence references in MGI

J:17960 Saida K, et al., A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity. J Biol Chem. 1989 Sep 5;264(25):14613-6
J:23581 Harats D, et al., Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J Clin Invest. 1995 Mar;95(3):1335-44
J:31149 Chan TS, et al., Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. Eur J Biochem. 1995 Dec 15;234(3):819-26
J:31183 Maemura K, et al., Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene. Genomics. 1996 Jan 15;31(2):177-84
J:34149 Kurama M, et al., Sequence and neuronal expression of mouse endothelin-1 cDNA. Biochim Biophys Acta. 1996 Jul 17;1307(3):249-53
J:103174 Herrera VL, et al., Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis. Physiol Genomics. 2005 Nov 17;23(3):257-68
J:163869 de Frutos S, et al., NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H356-63
J:175668 de Frutos S, et al., Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. Am J Physiol Cell Physiol. 2011 Aug;301(2):C441-50