Sequence Detail

ID/Version

P21956 Q3TBN5 Q9WTS3 Q3U8S9 P97800 Q9R1X9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Lactadherin;AltName: Full=MFGM;AltName: Full=Milk fat globule-EGF factor 8; Short=MFG-E8;AltName: Full=SED1;AltName: Full=Sperm surface protein SP47; Short=MP47;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 463 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mfge8	milk fat globule EGF and factor V/VIII domain containing	19	119	4	19

Sequence references in MGI

J:10818 Stubbs JD, et al., cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8417-21
J:46987 Ensslin M, et al., Molecular cloning and characterization of P47, a novel boar sperm-associated zona pellucida-binding protein homologous to a family of mammalian secretory proteins. Biol Reprod. 1998 Apr;58(4):1057-64
J:52429 Oshima K, et al., Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat globule glycoprotein MFG-E8. Biochem Biophys Res Commun. 1999 Jan 27;254(3):522-8
J:98314 Silvestre JS, et al., Lactadherin promotes VEGF-dependent neovascularization. Nat Med. 2005 Jun;11(6):499-506
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130766 Bu HF, et al., Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. J Clin Invest. 2007 Dec;117(12):3673-83
J:199057 Ye H, et al., NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine. Biochim Biophys Acta. 2013 Mar;1828(3):1083-93
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89