Sequence Detail

ID/Version

P21729 Q53WV4 (UniProt | EBI)

Last sequence update: 1991-08-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Gastrin-releasing peptide receptor; Short=GRP-R;AltName: Full=GRP-preferring bombesin receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 384 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grpr	gastrin releasing peptide receptor	45	102	3	20

Sequence references in MGI

J:11093 Spindel ER, et al., Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol Endocrinol. 1990 Dec;4(12):1956-63
J:28606 Battey JF, et al., Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):395-9
J:43565 Wada E, et al., Generation and characterization of mice lacking gastrin-releasing peptide receptor. Biochem Biophys Res Commun. 1997 Oct 9;239(1):28-33
J:63141 Weber HC, et al., Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. Gene. 2000 Feb 22;244(1-2):137-49
J:78753 Ladenheim EE, et al., Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice. J Endocrinol. 2002 Aug;174(2):273-81
J:80849 Shumyatsky GP, et al., Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell. 2002 Dec 13;111(6):905-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:123810 Sun YG, et al., A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature. 2007 Aug 9;448(7154):700-3
J:227985 Pereira PJ, et al., GRPR/PI3Kgamma: Partners in Central Transmission of Itch. J Neurosci. 2015 Dec 9;35(49):16272-81
J:229238 Li P, et al., The peptidergic control circuit for sighing. Nature. 2016 Feb 18;530(7590):293-7
J:240537 Yu YQ, et al., Molecular and neural basis of contagious itch behavior in mice. Science. 2017 Mar 10;355(6329):1072-1076
J:313601 Melzer S, et al., Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories. Cell. 2021 Oct 28;184(22):5622-5634.e25