Sequence Detail

ID/Version

P21447 Q5I1Y5 (UniProt | EBI)

Last sequence update: 2009-06-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ATP-dependent translocase ABCB1 {ECO:0000250|UniProtKB:P08183};AltName: Full=ATP-binding cassette sub-family B member 1A {ECO:0000305};AltName: Full=MDR1A;AltName: Full=Multidrug resistance protein 1A; EC=7.6.2.2 {ECO:0000250|UniProt

Provider

SWISS-PROT

Sequence

Polypeptide 1276 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcb1a	ATP-binding cassette, sub-family B member 1A	137	110	2	12

Sequence references in MGI

J:10391 Devault A, et al., Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol. 1990 Apr;10(4):1652-63
J:20011 Hsu SI, et al., Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells [published erratum appears in Mol Cell Biol 1990 Nov;10(11):6101]. Mol Cell Biol. 1990 Jul;10(7):3596-606
J:21795 Hsu SI, et al., Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes. J Biol Chem. 1989 Jul 15;264(20):12053-62
J:235270 van Helvoort A, et al., MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell. 1996 Nov 1;87(3):507-17
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89