Sequence Detail

ID/Version

P21440 B9EK77 Q6LCL9 (UniProt | EBI)

Last sequence update: 2011-06-28
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Phosphatidylcholine translocator ABCB4 {ECO:0000305}; EC=7.6.2.1 {ECO:0000269|PubMed:7912658};AltName: Full=ATP-binding cassette sub-family B member 4 {ECO:0000312|MGI:MGI:97569};AltName: Full=Multidrug resistance protein 2 {ECO:0000

Provider

SWISS-PROT

Sequence

Polypeptide 1276 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcb4	ATP-binding cassette, sub-family B member 4	45	99	3	10

Sequence references in MGI

J:2241 Buschman E, et al., mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J Biol Chem. 1992 Sep 5;267(25):18093-9
J:9293 Gros P, et al., Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol. 1988 Jul;8(7):2770-8
J:9805 Croop JM, et al., The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol. 1989 Mar;9(3):1346-50
J:10390 Raymond M, et al., Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol Cell Biol. 1990 Apr;10(4):1642-51
J:15531 Smit JJ, et al., Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 1993 Nov 5;75(3):451-62
J:18957 Ruetz S, et al., Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell. 1994 Jul 1;77(7):1071-81
J:22312 Oude Elferink RP, et al., Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest. 1995 Jan;95(1):31-8
J:32078 Chianale J, et al., Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse. Biochem J. 1996 Mar 15;314(Pt 3):781-6
J:33251 Oude Elferink RP, et al., Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein. J Lipid Res. 1996 May;37(5):1065-75
J:224749 Buschman E, et al., Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes. Mol Cell Biol. 1991 Feb;11(2):595-603
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89