Sequence Detail

ID/Version

P21279 Q6PFF5 (UniProt | EBI)

Last sequence update: 2009-07-07
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Guanine nucleotide-binding protein G(q) subunit alpha; EC=3.6.5.- {ECO:0000269|PubMed:20966218};AltName: Full=Guanine nucleotide-binding protein alpha-q;

Provider

SWISS-PROT

Sequence

Polypeptide 359 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gnaq	guanine nucleotide binding protein, alpha q polypeptide	94	107	3	20

Sequence references in MGI

J:42882 Offermanns S, et al., Defective platelet activation in G alpha(q)-deficient mice. Nature. 1997 Sep 11;389(6647):183-6
J:43412 Strathmann M, et al., G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9113-7
J:44598 Offermanns S, et al., Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14089-94
J:49140 Offermanns S, et al., Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J. 1998 Aug 3;17(15):4304-12
J:126146 Shi G, et al., Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med. 2007 Oct 29;204(11):2705-18
J:144763 Tsutsumi R, et al., Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol. 2009 Jan;29(2):435-47
J:155291 Wright CD, et al., Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res. 2008 Oct 24;103(9):992-1000
J:163474 Misra RS, et al., Galphaq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med. 2010 Aug 2;207(8):1775-89
J:201289 Vowinckel J, et al., Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling. FEBS Lett. 2012 Nov 2;586(21):3819-24
J:277872 Wu YC, et al., A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. Biochim Biophys Acta. 2013 Dec;1833(12):3145-3154
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:354165 Waldo GL, et al., Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science. 2010 Nov 12;330(6006):974-80