Sequence Detail

ID/Version

P21237 A2AII2 Q8CCH9 (UniProt | EBI)

Last sequence update: 1991-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Neurotrophic factor BDNF precursor form {ECO:0000305}; Short=proBDNF;AltName: Full=Brain-derived neurotrophic factor;Contains: RecName: Full=Neurotrophic factor BDNF;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 249 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bdnf	brain derived neurotrophic factor	108	135	3	48

Sequence references in MGI

J:17123 Ernfors P, et al., Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature. 1994 Mar 10;368(6467):147-50
J:18432 Hofer M, et al., Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 1990 Aug;9(8):2459-64
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105428 Pang PT, et al., Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 2004 Oct 15;306(5695):487-91
J:113019 Chen ZY, et al., Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science. 2006 Oct 6;314(5796):140-3
J:199564 Baeza-Raja B, et al., p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19;33(25):10221-34
J:214739 Glerup S, et al., SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
J:267910 Giza JI, et al., The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 2018 Jul 11;99(1):163-178.e6
J:274852 Glerup S, et al., SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Mol Psychiatry. 2016 Dec;21(12):1740-1751