Sequence Detail

ID/Version

P20033 (UniProt | EBI)

Last sequence update: 2024-01-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Platelet-derived growth factor subunit A; Short=PDGF subunit A;AltName: Full=PDGF-1;AltName: Full=Platelet-derived growth factor A chain;AltName: Full=Platelet-derived growth factor alpha polypeptide;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 211 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdgfa	platelet derived growth factor, alpha	109	153	4	35

Sequence references in MGI

J:25227 Rorsman F, et al., Characterization of the mouse PDGF A-chain gene. Evolutionary conservation of gene structure, nucleotide sequence and alternative splicing. Growth Factors. 1992;6(4):303-13
J:30469 Mercola M, et al., Selective expression of PDGF A and its receptor during early mouse embryogenesis. Dev Biol. 1990 Mar;138(1):114-22
J:33629 Bostrom H, et al., PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996 Jun 14;85(6):863-73
J:43767 Lindahl P, et al., Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development. 1997 Oct;124(20):3943-53
J:53738 Fruttiger M, et al., Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development. 1999 Feb;126(3):457-67
J:62574 Gnessi L, et al., Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice. J Cell Biol. 2000 May 29;149(5):1019-26
J:63212 Karlsson L, et al., Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development. 2000 Aug;127(16):3457-66
J:108040 Bostrom H, et al., PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn. 2002 Jan;223(1):155-62