Sequence Detail

ID/Version

P19137 F8VQ40 (UniProt | EBI)

Last sequence update: 2018-07-18
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Laminin subunit alpha-1;AltName: Full=Laminin A chain;AltName: Full=Laminin-1 subunit alpha;AltName: Full=Laminin-3 subunit alpha;AltName: Full=S-laminin subunit alpha; Short=S-LAM alpha;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 3083 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lama1	laminin, alpha 1	73	177	3	20

Sequence references in MGI

J:14176 Pan TC, et al., Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands. Eur J Biochem. 1993 Aug 1;215(3):733-40
J:14722 Deutzmann R, et al., Structural study of long arm fragments of laminin. Evidence for repetitive C-terminal sequences in the A-chain, not present in the B-chains. Eur J Biochem. 1988 Oct 15;177(1):35-45
J:30472 Hartl L, et al., The N terminus of laminin A chain is homologous to the B chains. Eur J Biochem. 1988 May 2;173(3):629-35
J:30473 Sasaki M, et al., Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains. J Biol Chem. 1988 Nov 15;263(32):16536-44
J:73859 Durbeej M, et al., Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro. Differentiation. 2001 Dec;69(2-3):121-34
J:75014 Garbe JH, et al., Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains. Biochem J. 2002 Feb 15;362(Pt 1):213-21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:371677 Montanaro F, et al., alpha-Dystroglycan is a laminin receptor involved in extracellular matrix assembly on myotubes and muscle cell viability. J Cell Biol. 1999 Jun 14;145(6):1325-40
J:371683 Langenbach KJ, et al., Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells. Muscle Nerve. 2002 Nov;26(5):644-53
J:371687 Zhou YW, et al., Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling. Biochemistry. 2006 Feb 21;45(7):2042-52
J:371689 Zhou Y, et al., Laminin-induced activation of Rac1 and JNKp46 is initiated by Src family kinases and mimics the effects of skeletal muscle contraction. Biochemistry. 2007 Dec 25;46(51):14907-16
J:371725 Montanaro F, et al., Laminin and alpha-dystroglycan mediate acetylcholine receptor aggregation via a MuSK-independent pathway. J Neurosci. 1998 Feb 15;18(4):1250-60