Sequence Detail

ID/Version

P18894 A0A0R4J203 Q64465 Q8VCW7 (UniProt | EBI)

Last sequence update: 2024-05-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=D-amino-acid oxidase; Short=DAAO; Short=DAMOX; Short=DAO; EC=1.4.3.3 {ECO:0000269|PubMed:1355365, ECO:0000269|PubMed:20567862, ECO:0000269|PubMed:20603179, ECO:0000269|PubMed:33484270};

Provider

SWISS-PROT

Sequence

Polypeptide 345 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dao	D-amino acid oxidase	65	99	5	9

Sequence references in MGI

J:1604 Konno R, et al., Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity. Int J Biochem. 1991;23(11):1301-5
J:2701 Sasaki M, et al., A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse. Biochim Biophys Acta. 1992 Aug 25;1139(4):315-8
J:10737 Tada M, et al., Cloning and expression of a cDNA encoding mouse kidney D-amino acid oxidase. Gene. 1990 Jun 15;90(2):293-7
J:15446 Konno R, et al., Origin of D-alanine present in urine of mutant mice lacking D-amino-acid oxidase activity. Am J Physiol. 1993 Oct;265(4 Pt 1):G699-703
J:21994 Hashimoto A, et al., Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. Neurosci Lett. 1993 Apr 2;152(1-2):33-6
J:39781 Konno R, et al., D-amino-acid oxidase is not present in the mouse liver. Biochim Biophys Acta. 1997 Apr 17;1335(1-2):173-81
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103798 Maekawa M, et al., Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase. Neurosci Res. 2005 Sep;53(1):34-8
J:107977 Wake K, et al., Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase. Neurosci Lett. 2001 Jan 5;297(1):25-8
J:111957 Almond SL, et al., Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. Mol Cell Neurosci. 2006 Aug;32(4):324-34
J:163969 Labrie V, et al., Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. Learn Mem. 2009 Jan;16(1):28-37
J:169206 Labrie V, et al., Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice. Genes Brain Behav. 2010 Feb;9(1):11-25
J:179975 Sasabe J, et al., D-Amino acid oxidase controls motoneuron degeneration through D-serine. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):627-32
J:182537 Nakamura H, et al., Protective Role of D-Amino Acid Oxidase against Staphylococcus aureus Infection. Infect Immun. 2012 Apr;80(4):1546-53
J:188896 Katane M, et al., Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment. Biochimie. 2010 Oct;92(10):1371-8
J:252623 Kondori NR, et al., Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. PLoS One. 2017;12(12):e0188912
J:253381 Pritchett D, et al., d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption. Eur J Neurosci. 2015 May;41(9):1167-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343144 Lombardo B, et al., D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans. Transl Psychiatry. 2022 Aug 1;12(1):305
J:343404 Katane M, et al., Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase. Amino Acids. 2011 Feb;40(2):467-76
J:343411 Konno R, et al., Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. J Nutr. 1984 Sep;114(9):1617-21
J:344201 Wu M, et al., D-dopa is unidirectionally converted to L-dopa by D-amino acid oxidase, followed by dopa transaminase. Clin Exp Pharmacol Physiol. 2006 Nov;33(11):1042-6
J:345006 Sasabe J, et al., Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol. 2016 Jul 25;1(10):16125
J:345044 Tuinema BR, et al., Salmonella evades D-amino acid oxidase to promote infection in neutrophils. mBio. 2014 Nov 25;5(6):e01886
J:345048 Murtas G, et al., Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota. Cell Mol Life Sci. 2021 Apr;78(7):3607-3620