Sequence Detail

ID/Version

P18155 Q3TMN4 (UniProt | EBI)

Last sequence update: 1990-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial;Includes: RecName: Full=NAD-dependent methylenetetrahydrofolate dehydrogenase; EC=1.5.1.15 {ECO:0000269|PubMed:2647744, ECO:0000269|PubMed:3487546}

Provider

SWISS-PROT

Sequence

Polypeptide 350 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mthfd2	methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase	45	112	3	14

Sequence references in MGI

J:9668 Belanger C, et al., Isolation and characterization of cDNA clones encoding the murine NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. J Biol Chem. 1989 Mar 25;264(9):4837-43
J:11015 Belanger C, et al., Structural organization of the murine gene encoding NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. Gene. 1991 Jan 15;97(2):283-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89