Sequence Detail

ID/Version

P17710 Q64479 Q61659 E9PXQ3 Q64476 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Hexokinase-1 {ECO:0000305}; EC=2.7.1.1 {ECO:0000250|UniProtKB:P19367};AltName: Full=Hexokinase type I {ECO:0000303|PubMed:9450953}; Short=HK I {ECO:0000303|PubMed:9450953};AltName: Full=Hexokinase, tumor isozyme {ECO:0000303|

Provider

SWISS-PROT

Sequence

Polypeptide 974 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hk1	hexokinase 1	95	110	3	16

Sequence references in MGI

J:13581 Mori C, et al., Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells. Biol Reprod. 1993 Aug;49(2):191-203
J:22166 Arora KK, et al., Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase. J Biol Chem. 1990 Apr 15;265(11):6481-8
J:46164 Travis AJ, et al., Targeting of a germ cell-specific type 1 hexokinase lacking a porin-binding domain to the mitochondria as well as to the head and fibrous sheath of murine spermatozoa. Mol Biol Cell. 1998 Feb;9(2):263-76
J:159554 Nakamura N, et al., Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5. Biol Reprod. 2010 Mar;82(3):504-15
J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
J:234642 Wolf AJ, et al., Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28;166(3):624-36
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89