Sequence Detail

ID/Version

P17208 E9QPT6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=POU domain, class 4, transcription factor 1;AltName: Full=Brain-specific homeobox/POU domain protein 3A; Short=Brain-3A; Short=Brn-3A;AltName: Full=Brn-3.0;

Provider

SWISS-PROT

Sequence

Polypeptide 421 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pou4f1	POU domain, class 4, transcription factor 1	94	188	3	15

Sequence references in MGI

J:10430 Goldsborough A, et al., Cloning and sequencing of POU-boxes expressed in mouse testis. Nucleic Acids Res. 1990 Mar 25;18(6):1634
J:16381 Theil T, et al., Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
J:18174 Theil T, et al., Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes. Cytogenet Cell Genet. 1994;66(4):267-71
J:30561 Theil T, et al., Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. J Biol Chem. 1995 Dec 29;270(52):30958-64
J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
J:35877 Xiang M, et al., Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11950-5
J:37869 Smith MD, et al., The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Mol Cell Biol. 1997 Jan;17(1):345-54
J:80023 Trieu M, et al., Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a. Development. 2003 Jan;130(1):111-21
J:183949 Zou M, et al., Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15;364(2):114-27
J:233585 Calissano M, et al., Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. Oncogene. 2003 Aug 21;22(35):5408-14
J:235271 Budhram-Mahadeo V, et al., The different activities of the two activation domains of the Brn-3a transcription factor are dependent on the context of the binding site. J Biol Chem. 1996 Apr 12;271(15):9108-13
J:239205 Schulze-Spate U, et al., Brn3 transcription factors control terminal osteoclastogenesis. J Cell Biochem. 2007 Sep 01;102(1):1-12
J:239215 Budhram-Mahadeo V, et al., POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol Cell Biol. 1998 Feb;18(2):1029-41