Sequence Detail

ID/Version

P17125 (UniProt | EBI)

Last sequence update: 1990-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transforming growth factor beta-3 proprotein;Contains: RecName: Full=Latency-associated peptide; Short=LAP;Contains: RecName: Full=Transforming growth factor beta-3; Short=TGF-beta-3;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 410 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tgfb3	transforming growth factor, beta 3	100	168	3	12

Sequence references in MGI

J:10366 Miller DA, et al., Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. Mol Endocrinol. 1989 Dec;3(12):1926-34
J:10745 Denhez F, et al., Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3. Growth Factors. 1990;3(2):139-46
J:21249 Watrin F, et al., Cell lineage specificity of expression of the murine transforming growth factor beta 3 and transforming growth factor beta 1 genes. Cell Growth Differ. 1991 Feb;2(2):77-83
J:29901 Proetzel G, et al., Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet. 1995 Dec;11(4):409-14
J:29902 Kaartinen V, et al., Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 1995 Dec;11(4):415-21
J:56561 Taya Y, et al., Pathogenesis of cleft palate in TGF-beta3 knockout mice. Development. 1999 Sep;126(17):3869-79
J:169435 Huser CA, et al., TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death Differ. 2010 Feb;17(2):304-15
J:248781 Wu BX, et al., Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) beta3 and is essential for mouse palatogenesis. J Biol Chem. 2017 Nov 03;292(44):18091-18097