About   Help   FAQ
Sequence Detail
ID/Version
P16388 (UniProt | EBI) Last sequence update: 1990-08-01
Last annotation update: 2015-03-04
Sequence
description
from provider
RecName: Full=Potassium voltage-gated channel subfamily A member 1;AltName: Full=MBK1 {ECO:0000303|PubMed:2451788};AltName: Full=MKI;AltName: Full=Voltage-gated potassium channel subunit Kv1.1;
Provider SWISS-PROT
Sequence
Polypeptide 495 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 72 3 5 5
Sequence references in MGI J:9129 Tempel BL, et al., Cloning of a probable potassium channel gene from mouse brain. Nature. 1988 Apr 28;332(6167):837-9
J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
J:19538 Wang H, et al., Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. J Neurosci. 1994 Aug;14(8):4588-99
J:38104 Donahue LR, et al., Megencephaly: a new mouse mutation on chromosome 6 that causes hypertrophy of the brain. Mamm Genome. 1996 Dec;7(12):871-6
J:47349 Smart SL, et al., Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron. 1998 Apr;20(4):809-19 HUMAN
J:54087 Zhang CL, et al., Specific alteration of spontaneous GABAergic inhibition in cerebellar purkinje cells in mice lacking the potassium channel Kv1. 1. J Neurosci. 1999 Apr 15;19(8):2852-64
J:77281 Zhou L, et al., Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: role of potassium channels under the myelin sheath in young nerves. J Neurosci. 1998 Sep 15;18(18):7200-15
J:89910 Petersson S, et al., Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly. Eur J Neurosci. 2003 Dec;18(12):3231-40
J:105296 Brew HM, et al., Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1. J Physiol. 2003 Apr 1;548(Pt 1):1-20
J:119491 Persson AS, et al., Kv1.1 null mice have enlarged hippocampus and ventral cortex. BMC Neurosci. 2007;8:10
J:149606 Glaudemans B, et al., A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin Invest. 2009 Apr;119(4):936-42
J:164091 Glasscock E, et al., Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy. J Neurosci. 2010 Apr 14;30(15):5167-75
J:170639 Fulton S, et al., Contribution of Kv1.2 Voltage-gated Potassium Channel to D2 Autoreceptor Regulation of Axonal Dopamine Overflow. J Biol Chem. 2011 Mar 18;286(11):9360-72
J:172237 Ma Z, et al., Evidence for presence and functional effects of Kv1.1 channels in beta-cells: general survey and results from mceph/mceph mice. PLoS One. 2011;6(4):e18213
J:178006 Fisahn A, et al., Acoustic startle hypersensitivity in Mceph mice and its effect on hippocampal excitability. Eur J Neurosci. 2011 Oct;34(7):1121-30
J:181571 Li KX, et al., Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2012 Feb;15(2):267-73
J:181606 Allen PD, et al., Kcna1 gene deletion lowers the behavioral sensitivity of mice to small changes in sound location and increases asynchronous brainstem auditory evoked potentials but does not affect hearing thresholds. J Neurosci. 2012 Feb 15;32(7):2538-43
J:197275 Yang SB, et al., Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers. J Physiol. 2012 Jun 1;590(Pt 11):2645-58
J:197938 Hao J, et al., Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron. 2013 Mar 6;77(5):899-914
J:197945 Simeone TA, et al., Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices. Neurobiol Dis. 2013 Jun;54:68-81
J:200208 Glasscock E, et al., Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels. J Physiol. 2012 Aug 15;590(Pt 16):3913-26
J:215654 Bhalla T, et al., Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol. 2004 Oct;11(10):950-6
J:215893 Wang H, et al., Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons. Nature. 1993 Sep 2;365(6441):75-9
J:217265 San-Cristobal P, et al., Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling. Kidney Int. 2014 Jan;85(1):94-102
J:217281 Almgren M, et al., Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement. Hippocampus. 2007;17(4):292-304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2015
MGI 5.21
The Jackson Laboratory