Sequence Detail

ID/Version

P16301 Q8K139 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphatidylcholine-sterol acyltransferase; EC=2.3.1.43 {ECO:0000269|PubMed:15654758, ECO:0000269|PubMed:19065001, ECO:0000269|PubMed:8820107};AltName: Full=1-alkyl-2-acetylglycerophosphocholine esterase; EC=3.1.1.47 {ECO:000

Provider

SWISS-PROT

Sequence

Polypeptide 438 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lcat	lecithin cholesterol acyltransferase	71	104	3	9

Sequence references in MGI

J:10166 Warden CH, et al., Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin: cholesterol acyltransferase gene. Evidence for expression in brain and testes as well as liver. J Biol Chem. 1989 Dec 25;264(36):21573-81
J:56071 Forte TM, et al., Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. J Lipid Res. 1999 Jul;40(7):1276-83
J:75567 Furbee JW Jr, et al., In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. J Lipid Res. 2002 Mar;43(3):428-37
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124830 Ng DS, et al., Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis. J Biol Chem. 2002 Apr 5;277(14):11715-20
J:149650 Hirsch-Reinshagen V, et al., LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins. J Lipid Res. 2009 May;50(5):885-93
J:150395 Zhao Y, et al., Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry. 2005 Jan 25;44(3):1013-25
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89