Sequence Detail

ID/Version

P16277 Q8K2M8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein kinase Blk; EC=2.7.10.2;AltName: Full=B lymphocyte kinase;AltName: Full=p55-Blk;

Provider

SWISS-PROT

Sequence

Polypeptide 499 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Blk	B lymphoid kinase	31	100	3	12

Sequence references in MGI

J:745 Dymecki SM, et al., Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk. J Biol Chem. 1992 Mar 5;267(7):4815-23
J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
J:87194 Tretter T, et al., Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk. J Exp Med. 2003 Dec 15;198(12):1863-73
J:93840 Malek SN, et al., Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7351-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:115080 Saijo K, et al., Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003 Mar;4(3):274-9
J:196163 Malhotra N, et al., A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18;38(4):681-93
J:266149 Mahajan S, et al., Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol Cell Biol. 1995 Oct;15(10):5304-11
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89