Sequence Detail

ID/Version

P16054 (UniProt | EBI)

Last sequence update: 1990-04-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein kinase C epsilon type; EC=2.7.11.13 {ECO:0000250|UniProtKB:Q02156};AltName: Full=nPKC-epsilon;

Provider

SWISS-PROT

Sequence

Polypeptide 737 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkce	protein kinase C, epsilon	138	110	4	16

Sequence references in MGI

J:45455 Wang QJ, et al., The catalytic domain of PKC-epsilon, in reciprocal PKC-delta and - epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation. Oncogene. 1998 Jan 8;16(1):53-60
J:49534 Schaap D, et al., Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity. FEBS Lett. 1989 Jan 30;243(2):351-7
J:106401 Stawowy P, et al., Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res. 2005 Jul 1;67(1):50-9
J:108886 Scruggs SB, et al., Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol. 2006 Apr;40(4):465-73
J:111048 McGettrick AF, et al., Trif-related adapter molecule is phosphorylated by PKC{varepsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9196-201
J:137601 Ikenoue T, et al., Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31
J:180456 Saurin AT, et al., The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol. 2008 Aug;10(8):891-901
J:180462 Xu TR, et al., Phosphorylation at Ser729 specifies a Golgi localisation for protein kinase C epsilon (PKCepsilon) in 3T3 fibroblasts. Cell Signal. 2007 Sep;19(9):1986-95
J:180475 Ivaska J, et al., PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J. 2005 Nov 16;24(22):3834-45
J:180491 Hernandez RM, et al., Biochemical and morphogenic effects of the interaction between protein kinase C-epsilon and actin in vitro and in cultured NIH3T3 cells. J Cell Biochem. 2001;83(4):532-46
J:201252 Durgan J, et al., The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. Biochem J. 2008 Apr 15;411(2):319-31
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:355636 Baffi TR, et al., mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 Apr 13;14(678)