Sequence Detail

ID/Version

P15919 A2AVN8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=V(D)J recombination-activating protein 1; Short=RAG-1;Includes: RecName: Full=Endonuclease RAG1; EC=3.1.-.-;Includes: RecName: Full=E3 ubiquitin-protein ligase RAG1; EC=2.3.2.27; AltName: Full=RING-type E3 ubiq

Provider

SWISS-PROT

Sequence

Polypeptide 1040 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rag1	recombination activating 1	46	121	3	41

Sequence references in MGI

J:1934 Mombaerts P, et al., RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 1992 Mar 6;68(5):869-77
J:10163 Schatz DG, et al., The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22;59(6):1035-48
J:16553 Sadofsky MJ, et al., Expression and V(D)J recombination activity of mutated RAG-1 proteins [published erratum appears in Nucleic Acids Res 1994 Feb 11;22(3):550]. Nucleic Acids Res. 1993 Dec 11;21(24):5644-50
J:58995 Landree MA, et al., Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev. 1999 Dec 1;13(23):3059-69
J:88204 Jones JM, et al., Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15446-51
J:149451 Hewitt SL, et al., RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 2009 Jun;10(6):655-64
J:158989 Grazini U, et al., The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. Mol Cell. 2010 Jan 29;37(2):282-93
J:159059 Yin FF, et al., Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol. 2009 May;16(5):499-508
J:159076 Yurchenko V, et al., The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev. 2003 Mar 1;17(5):581-5
J:159089 Kim DR, et al., Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev. 1999 Dec 1;13(23):3070-80
J:159276 Bellon SF, et al., Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster. Nat Struct Biol. 1997 Jul;4(7):586-91
J:181758 Kassmeier MD, et al., VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J. 2012 Feb 15;31(4):945-58