Sequence Detail

ID/Version

P15702 (UniProt | EBI)

Last sequence update: 1990-04-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Leukosialin;AltName: Full=B-cell differentiation antigen LP-3;AltName: Full=Leukocyte sialoglycoprotein;AltName: Full=Lymphocyte antigen 48; Short=Ly-48;AltName: Full=Sialophorin;AltName: CD_antigen=CD43;Contains: RecName: Full=CD43

Provider

SWISS-PROT

Sequence

Polypeptide 395 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spn	sialophorin	67	99	4	18

Sequence references in MGI

J:10530 Cyster J, et al., Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990 Apr;20(4):875-81
J:10632 Baecher CM, et al., cDNA cloning and localization of the mouse leukosialin gene (Ly48) to chromosome 7. Immunogenetics. 1990;31(5-6):307-14
J:10711 Dorfman KS, et al., The nucleotide sequence of Ly 48 (mouse leukosialin, sialophorin): the mouse homolog of CD43. Nucleic Acids Res. 1990 Aug 25;18(16):4932
J:18035 Shiota J, et al., A unique murine CD43 epitope Lp-3: distinct distribution from another CD43 epitope S7. Cell Immunol. 1994 May;155(2):402-13
J:65841 Wang W, et al., Identification and cloning of a CD43-associated Serine/Threonine kinase. Cell Immunol. 2000 Oct 10;205(1):34-9
J:94032 Allenspach EJ, et al., ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001 Nov;15(5):739-50
J:94072 van den Berg TK, et al., Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J Immunol. 2001 Mar 15;166(6):3637-40
J:136333 Cannon JL, et al., CD43 regulates Th2 differentiation and inflammation. J Immunol. 2008 Jun 1;180(11):7385-93
J:149128 Mody PD, et al., Signaling through CD43 regulates CD4 T-cell trafficking. Blood. 2007 Oct 15;110(8):2974-82
J:153536 Seo W, et al., CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis. Blood. 2009 Oct 22;114(17):3567-77
J:168874 Takai Y, et al., Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins. J Mol Biol. 2008 Sep 5;381(3):634-44
J:182870 Cannon JL, et al., CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011 Apr;22(7):954-63
J:255332 Velazquez F, et al., CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol. 2016 Feb 1;196(3):1305-1316
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89