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Sequence Detail
P15314 (UniProt | EBI) Last sequence update: 1990-04-01
Last annotation update: 2019-04-10
from provider
RecName: Full=Interferon regulatory factor 1; Short=IRF-1;
Polypeptide 329 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Irf1 interferon regulatory factor 1 59 11 9 14
Sequence references in MGI J:17555 Miyamoto M, et al., Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 1988 Sep 9;54(6):903-13
J:115304 Negishi H, et al., Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15136-41
J:137875 Fragale A, et al., IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression. J Immunol. 2008 Aug 1;181(3):1673-82
J:144079 Kim EJ, et al., Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1. Biochem Biophys Res Commun. 2008 Dec 19;377(3):952-6
J:160488 Stirnweiss A, et al., IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J Immunol. 2010 May 1;184(9):5179-85
J:183131 Brien JD, et al., Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog. 2011 Sep;7(9):e1002230
J:183979 Taniguchi T, et al., IRF family of transcription factors as regulators of host defense. Annu Rev Immunol. 2001;19:623-55

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last database update
MGI 6.14
The Jackson Laboratory