Sequence Detail

ID/Version

P15209 Q3TUF9 Q91XJ9 Q80WU0 (UniProt | EBI)

Last sequence update: 1990-04-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=BDNF/NT-3 growth factors receptor; EC=2.7.10.1 {ECO:0000269|PubMed:27457814};AltName: Full=GP145-TrkB/GP95-TrkB; Short=Trk-B;AltName: Full=Neurotrophic tyrosine kinase receptor type 2;AltName: Full=TrkB tyrosine kinase;Flags:

Provider

SWISS-PROT

Sequence

Polypeptide 821 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	133	162	4	37

Sequence references in MGI

J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
J:40431 Ninkina N, et al., TrkB variants with deletions in the leucine-rich motifs of the extracellular domain. J Biol Chem. 1997 May 16;272(20):13019-25
J:41358 Klein R, et al., The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 1990 May 18;61(4):647-56
J:41382 Soppet D, et al., The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. 1991 May 31;65(5):895-903
J:49434 Farinas I, et al., Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998 Aug;21(2):325-34
J:56847 Klein R, et al., Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 1993 Oct 8;75(1):113-22
J:58229 Minichiello L, et al., Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999 Oct;24(2):401-14
J:86332 Du J, et al., Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J Cell Biol. 2003 Oct 27;163(2):385-95
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130626 Minichiello L, et al., Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002 Sep 26;36(1):121-37
J:132562 Medina DL, et al., TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration. EMBO J. 2004 Oct 1;23(19):3803-14
J:169866 Chen AI, et al., TrkB (Tropomyosin-Related Kinase B) Controls the Assembly and Maintenance of GABAergic Synapses in the Cerebellar Cortex. J Neurosci. 2011 Feb 23;31(8):2769-80
J:180470 Miyamoto Y, et al., TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9
J:180478 Douma S, et al., Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature. 2004 Aug 26;430(7003):1034-9
J:180482 Rose CR, et al., Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 2003 Nov 6;426(6962):74-8
J:199564 Baeza-Raja B, et al., p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19;33(25):10221-34
J:205834 Rohe M, et al., SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PLoS One. 2013;8(8):e72164
J:239200 Fu X, et al., Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Mol Biol Cell. 2011 Oct;22(19):3684-98
J:274852 Glerup S, et al., SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Mol Psychiatry. 2016 Dec;21(12):1740-1751
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89