Sequence Detail

ID/Version

P14719 Q05208 (UniProt | EBI)

Last sequence update: 2002-12-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-1 receptor-like 1; EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};AltName: Full=Interleukin-33 receptor alpha chain {ECO:0000303|PubMed:18003919};AltName: Full=Lymphocyte antigen 84;AltName: Full=Protein ST2;AltName: F

Provider

SWISS-PROT

Sequence

Polypeptide 567 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il1rl1	interleukin 1 receptor-like 1	40	110	3	30

Sequence references in MGI

J:9936 Klemenz R, et al., Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5708-12
J:10165 Tominaga S, A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor. FEBS Lett. 1989 Dec 4;258(2):301-4
J:11397 Tominaga S, et al., Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping. Biochim Biophys Acta. 1991 Aug 27;1090(1):1-8
J:17250 Bergers G, et al., Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J. 1994 Mar 1;13(5):1176-88
J:17554 Yanagisawa K, et al., Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1. FEBS Lett. 1993 Feb 22;318(1):83-7
J:127627 Ali S, et al., IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18660-5
J:151287 Chackerian AA, et al., IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007 Aug 15;179(4):2551-5
J:160247 Drube S, et al., The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Blood. 2010 May 13;115(19):3899-906
J:172530 Yasuoka S, et al., Production and functions of IL-33 in the central nervous system. Brain Res. 2011 Apr 18;1385:8-17
J:187651 Zhao J, et al., F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat Immunol. 2012 Jul;13(7):651-8
J:274274 Osbourn M, et al., HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33. Immunity. 2017 Oct 17;47(4):739-751.e5
J:319416 Faas M, et al., IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021 Nov 9;54(11):2531-2546.e5