Sequence Detail

ID/Version

P14142 Q3TPK6 Q9JJN9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Solute carrier family 2, facilitated glucose transporter member 4 {ECO:0000305};AltName: Full=GT2 {ECO:0000303|PubMed:2654938};AltName: Full=Glucose transporter type 4, insulin-responsive {ECO:0000303|PubMed:10952468}; Short=GLUT-4 {

Provider

SWISS-PROT

Sequence

Polypeptide 509 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	123	124	2	12

Sequence references in MGI

J:16692 Kaestner KH, et al., Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes [published erratum appears in Proc Natl Acad Sci U S A 1989 Jul;86(13):4937]. Proc Natl Acad Sci U S A. 1989 May;86(9):3150-4
J:63673 Ueda H, et al., Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse. Diabetologia. 2000 Jul;43(7):932-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:176652 Xie X, et al., C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane. Cell Metab. 2011 Sep 7;14(3):378-89
J:234039 Beaton N, et al., TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. Mol Metab. 2015 Nov;4(11):795-810
J:236793 Bruno J, et al., SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol. 2016 Jul 4;214(1):61-76
J:262363 Fazakerley DJ, et al., Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. J Biol Chem. 2015 Sep 25;290(39):23528-42
J:265598 Ando Y, et al., Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2015 Feb 27;290(9):5881-92
J:265618 Liu T, et al., A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes. Sci Rep. 2016 Oct 14;6:35438
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89