Sequence Detail

ID/Version

P13504 (UniProt | EBI)

Last sequence update: 1990-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-1 receptor type 1; Short=IL-1R-1; Short=IL-1RT-1; Short=IL-1RT1; EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};AltName: Full=CD121 antigen-like family member A;AltName: Full=Interleukin-1 recep

Provider

SWISS-PROT

Sequence

Polypeptide 576 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il1r1	interleukin 1 receptor, type I	61	103	3	21

Sequence references in MGI

J:22685 Sims JE, et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science. 1988 Jul 29;241(4865):585-9
J:25951 Greenfeder SA, et al., Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem. 1995 Jun 9;270(23):13757-65
J:64697 Burns K, et al., Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2000 Jun;2(6):346-51
J:186478 Qian J, et al., Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12189-94
J:338375 Wang Y, et al., Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design. Immunity. 2023 Jul 11;56(7):1485-1501.e7