Sequence Detail

ID/Version

P12815 Q61145 Q545I0 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Programmed cell death protein 6;AltName: Full=ALG-257;AltName: Full=Apoptosis-linked gene 2 protein {ECO:0000303|PubMed:8560270}; Short=ALG-2 {ECO:0000303|PubMed:8560270};AltName: Full=PMP41;

Provider

SWISS-PROT

Sequence

Polypeptide 191 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdcd6	programmed cell death 6	119	96	3	12

Sequence references in MGI

J:33763 Vito P, et al., Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science. 1996 Jan 26;271(5248):521-5
J:37099 Kageyama H, et al., A partial cDNA for a novel protein which has a typical E-F hand structure. Biochim Biophys Acta. 1989 Jul 7;1008(2):255-7
J:53664 Missotten M, et al., Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ. 1999 Feb;6(2):124-9
J:76789 Jang IK, et al., Apoptosis-linked gene 2-deficient mice exhibit normal T-cell development and function. Mol Cell Biol. 2002 Jun;22(12):4094-100
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:177167 Tomsig JL, et al., Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. J Biol Chem. 2003 Mar 21;278(12):10048-54
J:201254 Draeby I, et al., The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. Arch Biochem Biophys. 2007 Nov 1;467(1):87-94
J:240322 Tanner JJ, et al., EF5 Is the High-Affinity Mg(2+) Site in ALG-2. Biochemistry. 2016 Sep 13;55(36):5128-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89