Sequence Detail

ID/Version

P12242 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitochondrial brown fat uncoupling protein 1 {ECO:0000305}; Short=UCP 1 {ECO:0000305};AltName: Full=Solute carrier family 25 member 7 {ECO:0000250|UniProtKB:P25874};AltName: Full=Thermogenin {ECO:0000250|UniProtKB:P04575};

Provider

SWISS-PROT

Sequence

Polypeptide 307 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	69	145	3	32

Sequence references in MGI

J:9318 Kozak LP, et al., The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains. J Biol Chem. 1988 Sep 5;263(25):12274-7
J:16058 Kozak UC, et al., An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol. 1994 Jan;14(1):59-67
J:40053 Enerback S, et al., Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [see comments]. Nature. 1997 May 1;387(6628):90-4
J:146646 Feldmann HM, et al., UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009 Feb;9(2):203-9
J:165318 Oelkrug R, et al., Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. J Biol Chem. 2010 Jul 16;285(29):21961-8
J:165368 Dlaskova A, et al., The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Biochim Biophys Acta. 2010 Aug;1797(8):1470-6
J:189069 Fedorenko A, et al., Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria. Cell. 2012 Oct 12;151(2):400-13
J:218161 Dempersmier J, et al., Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat. Mol Cell. 2015 Jan 22;57(2):235-46
J:235306 Chouchani ET, et al., Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 Apr 7;532(7597):112-6
J:289141 Jedrychowski MP, et al., Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proc Natl Acad Sci U S A. 2020 May 19;117(20):10789-10796
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89