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Sequence Detail
P12023 P97942 Q99K32 P97487 (UniProt | EBI) Last sequence update: 2003-05-09
Last annotation update: 2018-03-28
from provider
RecName: Full=Amyloid-beta A4 protein;AltName: Full=ABPP; Short=APP;AltName: Full=Alzheimer disease amyloid A4 protein homolog;AltName: Full=Amyloid precursor protein {ECO:0000305};AltName: Full=Amyloid-beta precursor protein {ECO:0000305};AltName
Polypeptide 770 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene App amyloid beta (A4) precursor protein 169 16 9 111
Sequence references in MGI J:994 Izumi R, et al., Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse. Gene. 1992 Mar 15;112(2):189-95
J:2308 De Strooper B, et al., The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochim Biophys Acta. 1991 Dec 2;1129(1):141-3
J:4115 Sola C, et al., Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry. Brain Res Mol Brain Res. 1993 Mar;17(3-4):340-6
J:9002 Yamada T, et al., Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. Biochem Biophys Res Commun. 1987 Dec 16;149(2):665-71
J:9929 Fukuchi K, et al., Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus. Nucleic Acids Res. 1989 Jul 11;17(13):5396
J:48365 Yamada T, et al., Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor. Biochem Biophys Res Commun. 1989 Feb 15;158(3):906-12
J:67339 Kumar VB, et al., Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8). Biochem Cell Biol. 2001;79(1):57-67
J:98747 Cappai R, et al., The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo. J Biol Chem. 2005 Apr 8;280(14):13913-20
J:101417 Andersen OM, et al., Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6
J:103763 Cao Q, et al., Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol Cell Biol. 2005 Dec;25(24):10930-9
J:113982 Taru H, et al., Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J Biol Chem. 2002 May 31;277(22):20070-8
J:114052 Matsuda S, et al., c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci. 2001 Sep 1;21(17):6597-607
J:166440 Norstrom EM, et al., Identification of NEEP21 as a ss-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17;30(46):15677-85
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:215903 Fernandez-Echevarria C, et al., Abeta promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease. Neuroscience. 2014 Oct 10;278:354-66
J:230367 Roncarati R, et al., The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7102-7
J:230384 Zambrano N, et al., The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J Biol Chem. 2001 Jun 8;276(23):19787-92

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last database update
MGI 6.12
The Jackson Laboratory