Sequence Detail

ID/Version

P11928 F2Z419 Q3UEC1 Q91VI0 Q64440 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=2'-5'-oligoadenylate synthase 1A; Short=(2-5')oligo(A) synthase 1A; Short=2-5A synthase 1A; EC=2.7.7.84 {ECO:0000269|PubMed:12396720, ECO:0000269|PubMed:15899864, ECO:0000269|PubMed:2171206, ECO:0000305|PubMed:2766372

Provider

SWISS-PROT

Sequence

Polypeptide 367 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Oas1a	2'-5' oligoadenylate synthetase 1A	71	98	2	9

Sequence references in MGI

J:11163 Rutherford MN, et al., The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res. 1991 Apr 25;19(8):1917-24
J:34026 Ichii Y, et al., Mouse 2-5A synthetase cDNA: nucleotide sequence and comparison to human 2-5A synthetase. Nucleic Acids Res. 1986 Dec 22;14(24):10117
J:34534 Coccia EM, et al., A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virology. 1990 Nov;179(1):228-33
J:99134 Yan W, et al., Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol. 2005 Jun;25(11):4615-24
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:175745 Kakuta S, et al., Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. J Interferon Cytokine Res. 2002 Sep;22(9):981-93
J:185034 Perelygin AA, et al., The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. J Mol Evol. 2006 Oct;63(4):562-76
J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7