Sequence Detail

ID/Version

P11881 P20943 Q99LG5 (UniProt | EBI)

Last sequence update: 2010-11-30
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 {ECO:0000305};AltName: Full=IP3 receptor isoform 1; Short=IP3R 1; Short=InsP3R1 {ECO:0000250|UniProtKB:Q14643};AltName: Full=Inositol 1,4,5 trisphosphate receptor {ECO:

Provider

SWISS-PROT

Sequence

Polypeptide 2749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itpr1	inositol 1,4,5-trisphosphate receptor 1	163	118	4	77

Sequence references in MGI

J:9499 Nordquist DT, et al., cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons. J Neurosci. 1988 Dec;8(12):4780-9
J:9928 Furuichi T, et al., Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum. Nucleic Acids Res. 1989 Jul 11;17(13):5385-6
J:10088 Furuichi T, et al., Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature. 1989 Nov 2;342(6245):32-8
J:73413 Nakagawa T, et al., The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6244-8
J:96085 Higo T, et al., Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell. 2005 Jan 14;120(1):85-98
J:153833 Li G, et al., Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol. 2009 Sep 21;186(6):783-92
J:170219 Yamazaki H, et al., Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. J Biol Chem. 2010 Nov 12;285(46):36081-91
J:180467 Antl M, et al., IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood. 2007 Jan 15;109(2):552-9
J:203544 Schulman JJ, et al., The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. J Biol Chem. 2013 Aug 30;288(35):25340-9
J:206880 Kim B, et al., The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes. Dev Biol. 2014 Feb 15;386(2):331-9
J:212812 Ando H, et al., IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem. 2003 Mar 21;278(12):10602-12
J:216755 Fredericks GJ, et al., Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16478-83
J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41
J:242232 Hamada K, et al., IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography. Proc Natl Acad Sci U S A. 2017 May 02;114(18):4661-4666
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347309 Akizawa H, et al., Zn(2+) is essential for Ca(2+) oscillations in mouse eggs. Elife. 2023 Dec 15;12
J:347310 Gao X, et al., Binding of the erlin1/2 complex to the third intralumenal loop of IP(3)R1 triggers its ubiquitin-proteasomal degradation. J Biol Chem. 2022 Jun;298(6):102026
J:347353 Sienaert I, et al., Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor. Biochem J. 2002 Jul 1;365(Pt 1):269-77
J:352564 Adkins CE, et al., Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors. Biochem J. 2000 Jan 15;345 Pt 2(Pt 2):357-63
J:354156 Bosanac I, et al., Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature. 2002 Dec 12;420(6916):696-700