Sequence Detail

ID/Version

P11688 E9QN40 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Integrin alpha-5;AltName: Full=CD49 antigen-like family member E;AltName: Full=Fibronectin receptor subunit alpha;AltName: Full=Integrin alpha-F;AltName: Full=VLA-5;AltName: CD_antigen=CD49e;Contains: RecName: Full=Integrin alpha-5 heavy ch

Provider

SWISS-PROT

Sequence

Polypeptide 1053 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itga5	integrin alpha 5 (fibronectin receptor alpha)	106	122	3	26

Sequence references in MGI

J:16248 Yang JT, et al., Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development. 1993 Dec;119(4):1093-105
J:31505 Holers VM, et al., Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II. J Exp Med. 1989 May 1;169(5):1589-605
J:66342 Alahari SK, et al., Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J Cell Biol. 2000 Dec 11;151(6):1141-54
J:93054 Alahari SK, et al., The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J. 2004 Jul 21;23(14):2777-88
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:334841 Kuramoto K, et al., Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise. Cell Metab. 2023 Feb 14;