Sequence Detail

ID/Version

P11416 P22603 (UniProt | EBI)

Last sequence update: 1989-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Retinoic acid receptor alpha; Short=RAR-alpha;AltName: Full=Nuclear receptor subfamily 1 group B member 1;

Provider

SWISS-PROT

Sequence

Polypeptide 462 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rara	retinoic acid receptor, alpha	248	189	4	99

Sequence references in MGI

J:9855 Zelent A, et al., Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature. 1989 Jun 29;339(6227):714-7
J:10956 Leroy P, et al., Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J. 1991 Jan;10(1):59-69
J:16002 Heiermann R, et al., Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1. J Recept Res. 1993;13(1-4):693-709
J:41344 Kruyt FA, et al., Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RAR alpha. Differentiation. 1992 Jan;49(1):27-37
J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
J:62059 Zhu Y, et al., Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J Biol Chem. 2000 May 5;275(18):13510-6
J:77521 Braun KW, et al., Positive regulation of retinoic Acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells. Biol Reprod. 2002 Jul;67(1):29-37
J:98529 Chung SS, et al., Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalities in spermiogenesis. Differentiation. 2005 Apr;73(4):188-98
J:144224 Bruck N, et al., A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters. EMBO J. 2009 Jan 7;28(1):34-47
J:149466 Williams JA, et al., Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. 2009 Apr 15;328(2):315-27
J:175162 Doyle TJ, et al., Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis. Ann N Y Acad Sci. 2007 Dec;1120:114-30
J:274785 Guyot R, et al., The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. BMC Mol Biol. 2010 Jan 15;11:3