Sequence Detail

ID/Version

P10820 (UniProt | EBI)

Last sequence update: 1990-04-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Perforin-1 {ECO:0000303|PubMed:2783549}; Short=P1;AltName: Full=Cytolysin;AltName: Full=Lymphocyte pore-forming protein;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 554 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prf1	perforin 1 (pore forming protein)	65	97	10	18

Sequence references in MGI

J:2869 Lichtenheld MG, et al., Structure and function of the murine perforin promoter and upstream region. Reciprocal gene activation or silencing in perforin positive and negative cells. J Immunol. 1992 Oct 15;149(8):2619-26
J:9295 Shinkai Y, et al., Homology of perforin to the ninth component of complement (C9). Nature. 1988 Aug 11;334(6182):525-7
J:9549 Lowrey DM, et al., Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9. Proc Natl Acad Sci U S A. 1989 Jan;86(1):247-51
J:9554 Kwon BS, et al., The structure of the mouse lymphocyte pore-forming protein perforin. Biochem Biophys Res Commun. 1989 Jan 16;158(1):1-10
J:10315 Trapani JA, et al., Genomic organization of the mouse pore-forming protein (perforin) gene and localization to chromosome 10. Similarities to and differences from C9. J Exp Med. 1990 Feb 1;171(2):545-57
J:17986 Kagi D, et al., Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice [see comments]. Nature. 1994 May 5;369(6475):31-7
J:21531 Walsh CM, et al., Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10854-8
J:21731 Lowin B, et al., A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11571-5
J:146737 Lowin B, et al., Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature. 1994 Aug 25;370(6491):650-2
J:175325 Law RH, et al., The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature. 2010 Nov 18;468(7322):447-51
J:326897 Nozaki K, et al., Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967
J:326899 Ivanova ME, et al., The pore conformation of lymphocyte perforin. Sci Adv. 2022 Feb 11;8(6):eabk3147
J:327044 Yagi H, et al., Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes. J Biol Chem. 2015 Oct 16;290(42):25213-26