Sequence Detail

ID/Version

P10810 (UniProt | EBI)

Last sequence update: 1989-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Monocyte differentiation antigen CD14;AltName: Full=Myeloid cell-specific leucine-rich glycoprotein;AltName: CD_antigen=CD14;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 366 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd14	CD14 antigen	86	100	2	14

Sequence references in MGI

J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
J:9844 Setoguchi M, et al., Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. Biochim Biophys Acta. 1989 Jul 7;1008(2):213-22
J:10572 Ferrero E, et al., CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J Immunol. 1990 Jul 1;145(1):331-6
J:32729 Haziot A, et al., Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 1996 Apr;4(4):407-14
J:98908 Jiang Z, et al., CD14 is required for MyD88-independent LPS signaling. Nat Immunol. 2005 Jun;6(6):565-70
J:116691 Gangloff SC, et al., Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol. 2005 Sep 15;175(6):3940-5
J:149492 Drage MG, et al., TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009;258(1):29-37
J:176269 Zhao J, et al., Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L547-56
J:222669 Tanimura N, et al., The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14