About   Help   FAQ
Sequence Detail
P10300 Q31127 Q61811 Q60966 (UniProt | EBI) Last sequence update: 1989-07-01
Last annotation update: 2019-12-11
from provider
RecName: Full=T-cell surface glycoprotein CD8 beta chain;AltName: Full=Lymphocyte antigen 3;AltName: Full=T-cell membrane glycoprotein Ly-3;AltName: Full=T-cell surface glycoprotein Lyt-3;AltName: CD_antigen=CD8b;Flags: Precursor;
Polypeptide 213 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Cd8b1 CD8 antigen, beta chain 1 9 1 5 8
Sequence references in MGI J:8738 Nakauchi H, et al., Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4210-4
J:9152 Gorman SD, et al., Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. J Immunol. 1988 May 15;140(10):3646-53
J:9389 Youn HJ, et al., Structure and expression of the Lyt-3a gene of C.AKR mice. Immunogenetics. 1988;28(5):353-61
J:9670 Nakayama K, et al., Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments. J Immunol. 1989 Apr 1;142(7):2540-6
J:19928 Fung-Leung WP, et al., Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice. J Exp Med. 1994 Sep 1;180(3):959-67
J:23845 Nakayama K, et al., Requirement for CD8 beta chain in positive selection of CD8-lineage T cells. Science. 1994 Feb 25;263(5150):1131-3
J:30886 Johnson-Tardieu JM, et al., Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8. Immunogenetics. 1996;43(1-2):6-12
J:113312 Chang HC, et al., Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity. 2005 Dec;23(6):661-71
J:113952 Doucey MA, et al., CD3 delta establishes a functional link between the T cell receptor and CD8. J Biol Chem. 2003 Jan 31;278(5):3257-64
J:144531 Angelov GS, et al., CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why?. Int Immunol. 2009 Feb;21(2):123-35
J:168951 Shore DA, et al., The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. J Mol Biol. 2008 Dec 31;384(5):1190-202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory