Sequence Detail

ID/Version

P0DOY1 A0A286YDX7 (UniProt | EBI)

Last sequence update: 2018-12-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=DNA (cytosine-5)-methyltransferase 3C {ECO:0000305}; Short=Dnmt3c {ECO:0000303|PubMed:27856912}; EC=2.1.1.37 {ECO:0000255|PROSITE-ProRule:PRU10018, ECO:0000269|PubMed:27856912, ECO:0000269|PubMed:39098534};

Provider

SWISS-PROT

Sequence

Polypeptide 740 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dnmt3c	DNA methyltransferase 3C	36	96	0	11

Sequence references in MGI

J:237199 Barau J, et al., The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016 Nov 18;354(6314):909-912
J:244795 Jain D, et al., rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet. 2017 Aug;13(8):e1006964
J:295943 Zoch A, et al., SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. Nature. 2020 Aug;584(7822):635-639
J:346376 Zoch A, et al., C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line. Mol Cell. 2024 Mar 21;84(6):1021-1035.e11
J:355645 Khudaverdyan N, et al., The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation. J Biol Chem. 2024 Aug 2;300(9):107633