Sequence Detail

ID/Version

P0C7A3 B1Q004 B2RWL6 (UniProt | EBI)

Last sequence update: 2008-04-08
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ghrelin O-acyltransferase {ECO:0000303|PubMed:18443287}; EC=2.3.1.- {ECO:0000269|PubMed:18443287, ECO:0000269|PubMed:18669668, ECO:0000269|PubMed:19501572, ECO:0000269|PubMed:24045953, ECO:0000269|PubMed:28134508, ECO:0000305|PubMed:

Provider

SWISS-PROT

Sequence

Polypeptide 435 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mboat4	membrane bound O-acyltransferase domain containing 4	23	97	3	11

Sequence references in MGI

J:134640 Gutierrez JA, et al., Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6320-5
J:139606 Yang J, et al., Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96
J:140051 Yang J, et al., Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10750-5
J:306584 Taylor MS, et al., Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem. 2013 Nov 8;288(45):32211-32228
J:314563 McGovern-Gooch KR, et al., Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation. Biochemistry. 2017 Feb 21;56(7):919-931
J:314647 Ohgusu H, et al., Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. Biochem Biophys Res Commun. 2009 Aug 14;386(1):153-8